MitoStem™
A universal T-cell quality enhancer designed to increase Tscm across donors, media, and protocols.
Key features:
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Mitochondrial reprogramming: biases T-cell fate toward long-lived immune memory cells
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Clinical compatibility: works with xeno-free media, cytokines, and vessels
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Process-ready: traceable, washable, and analytically detectable for regulatory confidence
MitoStem™ consistently increases Tscm
% Cells
Control
MitoStem
Less differentiated cells
CCR7+ CD45RA+ (Tscm)
CCR7+ CD45RA- (Tcm)
CCR7- CD45RA- (Tem)
CCR7- CD45RA+ (Temra)
Phenotypic markers
Figure 1.
Cells activated with TransAct and cultured for 10 days in 24-well G-REX plates in xeno-free medium with 30 IU/mL IL-2, 10 ng/mL IL-7 and 10 ng/mL IL-15
MitoGrow™
Drop-in manufacturing reagent that accelerates CAR-T expansion, shortening production timelines and lowering cost per dose.
Key features:
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Faster expansion:cuts manufacturing time by up to 20%
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Clinical compatibility: works universally across cell culture media and manufacturing systems.
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Process-ready: traceable, washable, and analytically detectable for regulatory confidence
MitoFit™
Drop-in manufacturing reagent that improves CAR-T metabolic fitness, resulting in stronger anti-tumor activity.
Key features:
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Enhanced in vivo efficacy: peer-reviewed performance in relevant tumor models (Cell Metabolism; Molecular Therapy Oncology)​
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Best-in-class metabolic modulation: outperforms established metabolic inhibitors ​
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Process-ready: traceable, washable, and analytically detectable for regulatory confidence
THE MITO RANGE
Plug-and-Play metabolic tools that enhance consistency, durability, and performance of CAR T cells.