MitoStemX | MPC Therapeutics

It's all about the cells.

MitoStemX boosts the fitness and persistence of T cells

By targeting key metabolic switches, MitoStemX drives
stem cell-like memory phenotype (Tscm).

A higher proportion of Tscm in the infused product correlates with improved clinical efficacy and durability. (Ref 1, Ref 2)

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MitoStemX creates products with up to 90% Tscm across multiple cell culture media

Experimental protocol

Cells grown in G-REX

Using leading xeno-free cell clinical grade culture media

Supplemented with IL-2, IL-7 and IL-15

Tscm cell surface markers: CD62L+, CD45RO-, CD45RA+, CCR7+

MitoStemX re-programs mitochondria

By targeting the Mitochondrial Pyruvate Carrier (MPC) and other key metabolic pathways, MitoStemX modulates mitochondrial function and improve the fitness, persistence, and therapeutic potential of T cells.

The mechanism of action involves a metabolic and epigenetic reprogramming of cells.

Our publications

A novel mitochondrial pyruvate carrier inhibitor drives stem cell-like memory CAR T cell generation and enhances antitumor efficacy, Wenes et al, Molecular Therapy Oncology, 2024

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function, Wenes et al, Cell Metabolism, 2022

It's all about the cells.

MitoStemX boosts the fitness and persistence of T cells

MitoStemX creates products with up to 90% Tscm across multiple cell culture media

Experimental protocol

Cells grown in G-REX

Using leading xeno-free cell clinical grade culture media

Supplemented with IL-2, IL-7 and IL-15

Tscm cell surface markers: CD62L+, CD45RO-, CD45RA+, CCR7+

MitoStemX re-programs mitochondria

Our publications

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